›› 2011, Vol. 31 ›› Issue (12): 1741-.doi: 10.3969/j.issn.1674-8115.2011.12.018

• Original article (Clinical research) • Previous Articles     Next Articles

Early and midterm outcomes of acute lower extremity deep venous thrombosis treated by catheter directed thrombolysis

YIN Min-yi, JIANG Mi-er, LI Wei-min, LU Xin-wu, HUANG Ying, HUANG Xin-tian, LU Min   

  1. Department of Vascular Surgery, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Vascular Center of Shanghai Jiaotong University, Shanghai 200011, China
  • Online:2011-12-28 Published:2012-01-04

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Abstract:

Objective To investigate the early and midterm outcomes of acute lower extremity deep venous thrombosis (DVT) treated by catheter directed thrombolysis (CDT). Methods Thirty-three patients with DVT underwent CDT treatment. The early outcome after CDT treatment was assessed by the rate of patency improvement and differences in circumference between impaired thigh and healthy thigh and between impaired leg and healthy leg after CDT treatment, and the midterm outcome was evaluated with percents of normal first valve in superficial femoral vein and venous clinical severity score (VCSS). Results The initial technical success rate of CDT treatment was 100%, with 5 cases of minor bleeding complications. The mean duration of CDT treatment was (3.93±1.14) d. The mean rate of patency improvement after treatment was (69.25±18.93)%. The differences in circumference between impaired thigh and healthy thigh and between impaired leg and healthy leg after treatment were significantly smaller than those before treatment(P<0.01, P<0.05). Twenty-nine patients were successfully followed up for 6 to 27 months. Three months and 6 months after treatment, the percents of normal first valve in superficial femoral vein in patients with thrombolysis grade Ⅱ and Ⅲ were significantly higher than that in patients with thrombolysis grade Ⅰ(P<0.05, P<0.01), and VCSS in patients with thrombolysis grade Ⅱ and Ⅲ were significantly lower than that in patients with thrombolysis grade Ⅰ(P<0.01). Conclusion Favorable early and midterm outcomes with less severe complications may be yielded in patients with acute lower extremity DVT treated by CDT.

Key words: catheter directed thrombolysis, deep venous thrombosis, postthrombotic syndrome