›› 2012, Vol. 32 ›› Issue (5): 670-.doi: 10.3969/j.issn.1674-8115.2012.05.031

• Review • Previous Articles     Next Articles

Research progress of correlation of bisphenol A with insulin resistance and type 2 diabetes

SUN Wan-wan, BI Yu-fang   

  1. Shanghai Institute for Endocrinology, Shanghai Clinical Center for Endocrine &|Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2012-05-28 Published:2012-06-01
  • Supported by:

    Key Special Program of Shanghai Science and Technology Committee, 09DZ1950200


Bisphenol A (BPA) is a chemical widely used in industrial manufacture, which is mainly applied for plastic utility production. People gain exposure to BPA via diet, breathing and skin contact in daily life. BPA has endocrine disrupting function, and is named as endocrine disrupting chemical. BPA may simulate estrogen function, which may influence pancreas islet B cells and estrogen-sensitive tissues such as adipocytes, hepatocytes and central nervous system, affect metabolism of glucose and fat, cause insulin resistance, influence differentiation of adipocytes and fat accumulation, and promote the development and progress of diabetes. Epidemiological studies have revealed that excessive exposure to BPA may promote the  development of metabolic diseases such as insulin resistance and type 2 diabetes. The correlation of BPA with development and progress of insulin resistance and type 2 diabetes is reviewed in this paper.

Key words: bisphenol A, type 2 diabetes, insulin resistance, endocrine disrupting chemicals