›› 2012, Vol. 32 ›› Issue (8): 1014-.doi: 10.3969/j.issn.1674-8115.2012.08.012

• Monographic report (Infertility and assisted reproductive technology) • Previous Articles     Next Articles

Research progress of endometrial receptivity markers

ZHANG Ping-gui, FENG Yun   

  1. Reproductive Medical Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2012-08-28 Published:2012-08-29


The low implantation rate is one of the major issues in the field of reproductive medicine, which has not been solved nowadays, and it also remains the major rate-limiting step in the development of human-assisted reproductive technology. Successful implantation requires a vital embryo and receptive endometrium. However, a large number of clinical trials have found that even if the embryo quality is good, the embryo implantation rate is continued low. The endometrium receptivity damage may be the main factor leading to low implantation rate. The better establishment of endometrial receptivity state may promote embryo-endometrial cross-talk, allowing the embryo implantation. The identification of endometrial receptivity markers is a prerequisite for improving endometrial receptivity. In recent years, the assessment of endometrial receptivity has become a research hotspot in reproductive medicine. The endometrial receptivity markers such as pinopodes, leukemia inhibitory factor (LIF) and homeobox A10 (HOXA10) gene are introduced in this paper.

Key words: in vitro fertilization-embryo transfer, embryo implantation, endometrial receptivity, marker