Abstract:

Objective To investigate the clinicopathological features, diagnosis, and differential diagnosis of serous microcystic adenoma (SMA) of pancreas. Methods The clinicopathological and immunohistochemical features of 2 cases of SMA of pancreas were analysed and relevant literatures were reviewed. Results Both 2 patients were female. The clinical symptoms were abdominal distension and pain. Neoplasms were well demarcated frequently with multicystic appearance on section. Microscopically, the tumors were composed of numerous microcysts lined by a single layer of cuboidal cells. The stroma of tumor was found to contain thick or thin fibrous tissue. Both cases were accompanied with polycyst of both kidneys, and one case was also accompanied with hemangioblastoma of liver and gastric adenocarcinoma. CK7, CK19, CK8/18, EMA, Muc1, and NSE were positive and CEA, CgA, and Syn were negative. No recurrence was found during the follow-up of 12-23 months. Hemangioblastoma of retina or central nervous system was not occurred in patients and their relatives. Conclusion SMA is a rare benign tumor of pancreas. A definite diagnosis can be made according to the radiological, morphological, and immunohistochemical features. SMA may not be a single disease and is often accompanied with multiple organ lesions. This suggests that the clinician should pay attention to examining other organs of SMA patients.

Key words: serous microcystic adenoma, pancreas, immunohistochemistry