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Advances of differentiation of neural stem cells regulated by long non-coding RNAs

HU Guo-wen1, ZHOU Xiang1, WANG Yang2, DENG Zhi-feng1,3   

  1. 1.Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China； 2.Institute for Microsurgery of Extremities, the Sixth People's Hospital， Shanghai Jiao Tong University, Shanghai 200233, China； 3.Department of Neurosurgery, the Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2014-07-28 Published:2014-08-11
  • Supported by:

    National Nature Science Foundation of China，81272170

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Abstract:

Long non-coding RNAs (lncRNA) is the largest class of ncRNAs with a transcript length from 200 to several thousand nucleotides and have no known proteincoding potential. LncRNAs can regulate the gene expression at epigenetic, transcriptional, and post-transcriptional levels through a wide range of mechanisms. More and more studies suggest that lncRNAs play a critical role in the development of central nervous system. Some types of lncRNAs can regulate the differentiation of neural stem cells (NSCs) towards neuronal lineages, while other types of lncRNAs can regulate the differentiation of NSCs towards neuroglia lineages. This paper reviews the latest progresses of studies on the differentiation of NSCs regulated by lncRNAs and provides new ideas for exploring the development of the nerve system.

Key words: long non-coding RNAs, neural stem cells, cell differentiation