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Application of multi-voxel magnetic resonance spectroscopy in differential diagnosis for low grade gliomas

ZHAO Qian1, SHI Chang-zheng2, LUO Liang-ping2, ZHOU Hui-ling2   

  1. 1.Department of Statistics, School of Public Health, Guangzhou Medical University, Guangzhou 510182, China; 2.Medical Imaging Center, the First Affiliated Hospital, Jinan University, Guangzhou 510630, China
  • Online:2014-08-28 Published:2014-09-02
  • Supported by:

    National Natural Science Foundation, 81202284; Guangdong Provincial Natural Science Foundation，S2011040004735; Project for Outstanding Young Innovative Talents in Colleges and Universities of Guangdong Province，LYM11106

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Abstract:

Objective To evaluate the performance of multi-voxel magnetic resonance spectroscopy (MRS) in differentiating low grade gliomas. Methods Retrospective study was done on 30 cases of grade Ⅱ gliomas (16 cases of astrocytoma and 14 cases of oligodendroglioma) who received MRS. Concentrations of metabolites and relative ratios were compared between the subtype astrocytoma and oligodendroglioma. Stepwise Logistic regression was applied to find the related factors. Results The relative concentrations of Cho and Cr from astrocytoma were higher than those of oligodendroglioma. The relative ratios Cho/Cr and Cho/NAA were also higher than those of oligodendroglioma （P<0.05）. Cho was the related factors in differentiating low grade astrocytoma and oligodendroglioma by Logistic regression model (OR=1.153，95%CI: 1.083-1.227，P<0.05). Conclusion The relative concentrations of Cho could be the important indexes to differentiate astrocytoma and oligodendroglioma in clinic.

Key words: magnetic resonance imaging, rain gliomas, agnetic resonance spectroscopy