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Analysis of treadmill exercise test for patients with type 2 diabetes mellitus combining metabolic syndrome

WAN Jin1, WANG Guang-yao2, HE An-xia1, ZHU Lei1, WANG Zhi-xiang1, YANG Zong-mei3, JIANG Lei-lei1   

  1. 1.Department of Cardiology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing 210029, China; 2.College of Basic Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210023, China; 3.Department of Internal Medicine, Nanjing Qinhuai Hospital, Nanjing 210000, China
  • Online:2014-08-28 Published:2014-09-02

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Abstract:

Objective To explore the characteristics and clinical significance of treadmill exercise test (TET) for patients with type 2 diabetes mellitus (T2DM) combining metabolic syndrome (MS). Methods A total of 184 cases of T2DM with paroxysmal chest pain were retrospectively analyzed. All patients underwent TET and coronary angiography (CAG) and were divided into the MS group (n=96) and non-MS group (n=88). The health control group (n=96) was also established. Indexes relevant to TET were compared and analyzed among three groups. The correlation of abdominal circumference and ST-segment depression was studied by the linear correlation analysis. Results The distribution of age and gender of three groups matched. The results of TET of three groups showed that the positive rate of the MS group was the highest; the positive rate of the non-MS group was low; and the positive rate of the control group was the lowest. The differences were statistically significant (P<0.05 or P<0.01). For patients with increased abdominal circumference, the positive rate of the MS group was the highest; the positive rate of the non-MS group was low; and the positive rate of the control group was the lowest. The differences were statistically significant (P<0.05). The increase of abdominal circumference was positively and significantly correlated to the ST-segment depression (for male r=0.766, P<0.01 and for female r=0.617,  P<0.01). Conclusion The results of TET show that most patients with T2DM combing MS present different degrees of myocardial ischemia and many abnormal indexes during exercise, which indicate in order to achieve early detection and evaluation of myocardial ischemia, TET should be routinely conducted for hospitals in which MS patients can not undergo the CAG. The degree of myocardial ischemia of most MS patients with increased abdominal circumference aggravates. Therefore those patients should control and decrease the abdominal circumference.

Key words: treadmill exercise test, type 2 diabetes mellitus, metabolic syndrome