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Application of proteomics to the study on Candida albicans

LIU Jin-yan1, SHI Ce2, WANG Ying2, LI Wen-jing2, ZHAO Yue2, ZHU Wei-wei1, XIANG Ming-jie1, 2   

  1. 1.Department of Laboratory Medicine, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China; 2.Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

  • Online:2016-12-28 Published:2016-12-29
  • Supported by:

    Program of Shanghai Key Specialty, ZK2012A21; Program of Excellent Youth Talents of Shanghai Municipal Huangpu District Health Bureau of China, RCPY1407

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Abstract:

Candida albicans (C.albicans) is the most common opportunistic human fungal pathogen causing invasive candidiasis, which is one of factors resulting in increasing morbidity and mortality in immunocompromised patients. Currently, limited types of antifungal drugs for clinical application, increased drug resistance, and slow progress of new drug development lead to more and more challenges in clinical treatment. Recently developed proteomics can provide a novel effective technology platform and has been applied to the study of C.albicans, including pathogenic factors, resistance mechanism, immune response, action mechanism of antifungal drugs, etc. In this paper, new development of proteomic technology and its application to the study on C.albicans were reviewed.

Key words: proteomics, mass spectrometry, Candida albicans