›› 2018, Vol. 38 ›› Issue (5): 569-.doi: 10.3969/j.issn.1674-8115.2018.05.018

• Review • Previous Articles     Next Articles

Research progress of β-propeller protein-associated neurodegeneration

ZHANG Chao1, 2, CAO Li2   

  1. 1. School of Medicine, Anhui University of Science and Technology, Huainan 232001, China; 2. Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2018-05-28 Published:2018-05-28
  • Supported by:
    National Natural Science Foundation of China, 81571086; Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Support, 20161401; Interdisciplinary Project of Shanghai Jiao Tong University, YG2016MS64

Abstract: β-Propeller protein-associated neurodegeneration (BPAN) is an X-linked hereditary disease causedWDR45 gene mutation with highly clinical heterogeneity and genetic heterogeneity. The disease has a two-phase clinical process, and clinical manifestations of childhood and adolescence or early adult stages are different. Main features are childhood development delay with seizures, and adolescence or early adult dystonia with Parkinsons syndrome and cognitive dysfunction, leading to severe disability. Childhood symptoms usually improve during adolescence and early adulthood. Imaging manifestations of pale globular and substantia nigra show anomalous iron deposits. This review summarized the clinical features and molecular genetics of BPAN.

Key words: &, beta, -propeller protein, WD repeat protein 45, neurodegeneration

CLC Number: