›› 2018, Vol. 38 ›› Issue (7): 719-.doi: 10.3969/j.issn.1674-8115.2018.07.001

• Review for outstanding international article • Previous Articles     Next Articles

Ubiquitin-like modification (SUMOylation) and genomic stability

CHENG Jin-ke   

  1. Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University College of Basic Medical Sciences; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai 200025, China
  • Online:2018-07-28 Published:2018-07-30
  • Supported by:
    National Natural Science Foundation of China，81430069，81721004

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Abstract: The mechanism of protein post-translational modifications in regulation of cell mitosis and genomic stability is always a hot issue in biological researches. The present review introduced the functional activity of de-SUMOylase SENP3 in sister chromatin dissociation at mitosis, and demonstrated a new molecular mechanism of cross-talk regulation between protein SUMOylation and phosphorylation in maintaining genomic stability.

Key words: SUMOylation, phosphorylation, SENP3

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