›› 2020, Vol. 40 ›› Issue (2): 200-.doi: 10.3969/j.issn.1674-8115.2020.02.009

• Original article (Clinical research) • Previous Articles     Next Articles

Meta-analysis of topiramate to improve body weight increase causedatypical antipsychotic drugs

WANG Dan-dan, WANG Ye-wei, FANG Xin-yu, CHEN Yan, YU Ling-fang, ZHANG Chen   

  1. Department of Biochemistry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-02-28 Published:2020-03-20
  • Supported by:
    National Key R&D Program of China (2018YFC1314302); National Natural Science Foundation of China (81771450, 81471358); Western Medicine Guide Project of Shanghai Municipal Science and Technology Commission (14411969000); Foundation of Shanghai Municipal Commission of Health and Family Planning (201540029).

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Abstract: Objective · To systematically evaluate the effect of topiramate on reducing body weight increase causedatypical antipsychotic drugs. Methods · A literature search was performedusing PubMed database, Embase database, PsycINFO database, Cochrane Library, CNKI, WanFang data and SinoMed. Randomized placebo-controlled trials of topiramate targeting weight-gain causedatypical antipsychotic drugs inception to Mar. 2019. Two researchers independently screened literatures according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality of included studies. The meta-analysis was performed using RevMan 5.3 software. Results · A total of 20 randomized controlled trials were included, consisting of 1 024 subjects. The results of meta-analysis showed that topiramate was significant effective in reducing atypical antipsychotic-related weight gain [weighted mean difference (WMD)-4.09, 95% CI -5.74 - -2.44, P0.000]. The body mass index (BMI) was also improved significantly (WMD-2.42, 95% CI -3.02 - -1.82, P0.000). Conclusion · Topiramate can effectively improve the body weight and BMI increase causedatypical antipsychotic drugs.

Key words: topiramate, atypical antipsychotic drug, body weight, body mass index (BMI)