›› 2020, Vol. 40 ›› Issue (2): 208-.doi: 10.3969/j.issn.1674-8115.2020.02.010

• Original article (Clinical research) • Previous Articles     Next Articles

Psychological mechanism of event-based prospective memory deficit in patients with first-episode schizophrenia

LI Xuan, XIANG Qiong, ZHAN Yan, ZHU Dian-ming, ZHUO Kai-ming, WANG Ya, CHEN Hai-ying, LIU Deng-tang   

  1. 1. Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Psychiatric Department, Shanghai Xuhui District Mental Health Center, Shanghai 200030, China; 3. Key Laboratory of Mental Health, Institution of Psychology, Chinese Academy of Sciences, Beijing 100101, China
  • Online:2020-02-28 Published:2020-03-20
  • Supported by:
    National Natural Science Foundation of China (81371479, 81871047); Key Program of Multidisciplinary Cross Research Foundation of Shanghai Jiao Tong University (YG2017ZD13); Key Program of Clinical Research Center of Shanghai Mental Health Center (CRC2017ZD03); Early Psychosis Program of Shanghai Mental Health Center (2013-YJTSZK-05).

Abstract: Objective · To analyze the difference of the event-based prospective memory (PM) between first-episode schizophrenia (FES) patients and normal patients, and to explore its possible psychological mechanism. Methods · Thirty-four FES patients without medication (FES group) and 31 healthy volunteers (healthy control group) were enrolled. Cue identification and intention retrieval components of event-based PM were examinedusing dual-task paradigm. Besides, verbal working memory was assessedLetter-Number Span, retrospective memory was assessedcomprehension memory test, and multitasking capability was assessedmodified six-element test (MEST). The mental symptoms and their severity were evaluatedPositive and Negative Symptom Scale (PANSS), Clinician-Rated Dimensions of Psychosis Symptom severity (CRDPS) and Clinical Global Impression (CGI). Results · The cue identification PM and intention retrieval PM in the FES group were significantly lower than those in the healthy control group (all PP0.000), while there was no significant difference in the multitasking capability between the two groups. After the working memory, retrospective memory and executive function being controlled, the difference in cue identification and intention retrieval of the two groups were still significant (both P0.000). Besides, there was no significant correlation between clue recognition ability and intention extraction ability of schizophrenia and clinical symptoms. Conclusion · Both cue identification deficit and intention retrieval deficit in event-based PM may be primary cognitive defects in patients with schizophrenia.

Key words: schizophrenia, prospective memory (PM), cue identification, intention retrieval