JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (7): 972-976.doi: 10.3969/j.issn.1674-8115.2021.07.021

• Review • Previous Articles    

Review of the factors influencing bone metabolism in schizophrenia

Hong-yan XUAN1,2(), Li-hua WANG1, Hua-fang LI1,3,4()   

  1. 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
    2.Department of Psychiatry, Shanghai Changning Mental Health Center, Shanghai 200335, China
    3.Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, China
    4.Shanghai Clinical Research Center for Mental Health, Shanghai 200030, China
  • Online:2021-07-28 Published:2021-08-03
  • Contact: Hua-fang LI;
  • Supported by:
    Shanghai Clinical Research Center for Mental Health(19MC1911100);Project of Shanghai Municipal Commission of Health and Family Planning(201740089)


The patients with schizophrenia experience a higher rate of low bone mineral density, osteoporosis and fractures than the general population, which affects not only their quality of life but also their long-term outcomes. Previous studies have shown that there are many factors affecting individual bone metabolism, including drugs, gender, age, hypogonadism, lifestyle, etc. Combined with clinical research, this article summarizes three aspects, i.e.,the disease itself, the use of antipsychotics and the unhealthy lifestyle. This review aims to discuss the influencing factors of bone metabolism in the patients with schizophrenia, and then expound briefly on the diagnosis and intervention measures of osteoporosis, which may provide a reference for clinical prevention and intervention of osteoporosis in the patients with schizophrenia.

Key words: schizophrenia, osteoporosis, bone metabolism, antipsychotics

CLC Number: