JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (2): 223-227.doi: 10.3969/j.issn.1674-8115.2021.02.015

• Public health • Previous Articles     Next Articles

Correlation between healthy vascular aging and prevalent cardiovascular disease risk in middle-aged and elderly people in the community of Shanghai

Hua-jie DAI(), Li-ping XUAN, Jia-li XIANG, Hong LIN, Zhi-yun ZHAO, Tian-ge WANG, Mian LI, Yu XU, Jie-li LU, Wei-qing WANG, Yu-fang BI, Min XU()   

  1. Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Metabolic Diseases; Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China
  • Received:2020-05-29 Online:2021-02-28 Published:2021-02-28
  • Contact: Min XU;
  • Supported by:
    Shanghai Science and Technology Commission Special Funds(YDZX20173100004881);Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center(SHDC12016202);Innovative Research Team of High-Level Local Universities in Shanghai;Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152508)

Abstract: Objective

·To study the correlation between healthy vascular aging (HVA) and prevalent cardiovascular diseases (CVDs) risk in middle-aged and elderly people in the community of Shanghai.


·A total of 9 922 participants aged 40 and above who lived in a Jiading community of Shanghai were included. The questionnaire interview, physical examination, biochemical index detection and brachial-ankle pulse wave velocity (baPWV) measurement were conducted in all participants. According to HVA status, the participants were divided into HVA group and non-HVA group. HVA was defined as baPWV≤15.20 m/s with no history of hypertension. The CVDs include stroke, myocardial infarction and coronary atherosclerotic heart disease. Logistic regression model was used to analyze the correlation between HVA and prevalent CVDs risk.


·Compared with those in the non-HVA group, the age, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, low density lipoprotein-cholesterol, fasting blood glucose, serum creatinine, baPWV and prevalence of diabetes mellitus and lipid disorders in the HVA group were lower, and the proportion of education level (high school or above) and estimated glomerular filtration rate in the HVA group were higher in both men and women (all P=0.000). Logistic regression analysis showed that after multiple confounding factors being adjusted, prevalent CVDs risk in the HVA group was significantly lower than that in the non-HVA group (OR=0.53, 95%CI 0.41?0.69, P=0.000).


·HVA is significantly associated with a lower risk of CVDs in middle-aged and elderly people (aged≥40) in the community of Shanghai, which suggests that HVA can be used as a potential indicator of CVDs prevention.

Key words: healthy vascular aging (HVA), cardiovascular disease (CVD), middle-aged and elderly people

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