JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (4): 540-545.doi: 10.3969/j.issn.1674-8115.2021.04.021

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Advance in research of interference effect of perfluorinated compounds on sexhormones

Zi-xia WANG1(), Qian YAO1, Ying TIAN1,2()   

  1. 1.Department of Environmental Health, Shanghai Jiao Tong University School of Public Health, Shanghai 200025, China
    2.MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Received:2020-03-03 Online:2021-04-28 Published:2021-05-14
  • Contact: Ying TIAN;
  • Supported by:
    National Natural Science Foundation of China(81773387);Interdisciplinary Program of Shanghai Jiao Tong University(YG2017MS84)


Perfluorinated compounds (PFCs) are a class of persistent organic pollutants that are widely distributed in the environment and biota. Studies have shown that PFCs have liver-toxicity, immune-toxicity and neuro-toxicity, etc. In recent years, due to an increasing number of studies suggesting that PFCs have endocrine disrupting effects, their reproductive toxicity has attracted much attention, especially their interference with the synthesis and secretion of sex hormone which may induce abnormalities in sexual differentiation and development, reproductive disorders, etc.This article reviews the relationship of PFCs with sex hormone levels and the potential mechanisms from animal toxicology experiments and epidemiological studies, thus providing the theoretical basis for PFCs research in the future.

Key words: perfluorinated compound, persistent organic pollutant, sex hormone

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