Meta analysis of correlation between lipid accumulation product and hypertension in Chinese adults

doi:10.3969/j.issn.1674-8115.2023.04.009

Abstract

Abstract:

Objective ·To explore the correlation between lipid accumulation product (LAP) and hypertension in Chinese adults. Methods ·By searching the English literature databases including PubMed and Web of Science, and the Chinese literature databases including CNKI and WanFang Data Knowledge Service Platform database, the earliest literature related to LAP and hypertension in Chinese adults that could be retrieved from databases establishment to August 2022. Two researchers independently screened all the retrieved literature according to the inclusion and exclusion criteria, and used the diagnostic research scale developed by Joanna Briggs Institute (JBI) to evaluate the literature quality of the selection, comparability, exposure evaluation and results of the study population. The sample size, gender, sensitivity, specificity and other information were extracted from the included literature. Stata 16.0 software was used for meta-analysis. Results ·A total of 6 articles were included, including five in English and one in Chinese. The JBI bias scores of the included articles ranged from 14 to 17 points, all of which were greater than 70% of the total score, so the biases could be considered small. The total number of samples included was 48 329, including 15 746 patients with hypertension. The results of meta-analysis showed that in the total population, the sensitivity of LAP in predicting hypertension was 0.50 (95%CI 0.35?0.64), and the specificity was 0.78 (95%CI 0.66?0.86); In women, the sensitivity was 0.48 (95%CI 0.32?0.64), and the specificity was 0.77 (95%CI 0.64?0.86); In males, the sensitivity was 0.56 (95%CI 0.39?0.72), and the specificity was 0.64 (95%CI 0.49?0.77). The area under the summary receiver operator characteristic curve (SROC curve) of the total population included was 0.70 (95%CI 0.66?0.74), indicating that there was a certain correlation between LAP and hypertension. Conclusion ·In Chinese adult population, LAP is associated with hypertension to a certain extent.

Key words: lipid accumulation product (LAP), hypertension, adult, Chinese, meta-analysis

CLC Number:

R181.3⁺7

MA Zhuoran, YUAN Ancai, JIANG Huiru, CHEN Xiaoyu, ZHANG Wei, PU Jun. Meta analysis of correlation between lipid accumulation product and hypertension in Chinese adults[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(4): 466-473.

Figures/Tables 5

TrendMD

References 43

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The first author	Research area	Study time	Hypertension definition	Research type	Total sample size	Number of patients with hypertension	Quality score/point
YAN	Pudong New Area, Shanghai	January, 2012‒March, 2013	Systolic blood pressure (SBP) ≥ 140 mmHg, diastolic blood pressure (DBP) ≥ 90 mmHg, or a history of oral antihypertensive medication	Cross-sectional study	2 092	1 066	15
SONG	Bengbu, Anhui Province	2018	SBP≥140 mmHg, DBP≥90 mmHg, or the subject reported with a medical history of antihypertensive medication	Cross-sectional study	1 777	433	14
WANG	Liaoning Province	2012	Blood pressure level of at least 140/90 mmHg, individuals who were on antihypertensive medications or a prior diagnosis of hypertension	Cross-sectional study	11 400	5 684	17
HUANG	Foshan, Fujian Province	2017	Prehypertension was defined as SBP 120‒139 mmHg and/or DBP 80‒89 mmHg, and hypertension was defined as SBP≥140 mmHg, DBP≥90 mmHg and/or a reported medical history of antihypertensive medication	Cross-sectional study	1 681	458	17
LEE	The Taiwan region	2022	Hypertension was defined as a self-reported history, SBP≥140 mmHg, or DBP≥90 mmHg during follow-up	Cohort study	21 466	3 157	16
LUO	Dalian, Liaoning Province	2011	Blood pressure≥140/90 mmHg and/or persons with confirmed hypertension and receiving treatment	Cross-sectional study	9 913	4 948	14

The first author	Research area	Study time	Hypertension definition	Research type	Total sample size	Number of patients with hypertension	Quality score/point
YAN	Pudong New Area, Shanghai	January, 2012‒March, 2013	Systolic blood pressure (SBP) ≥ 140 mmHg, diastolic blood pressure (DBP) ≥ 90 mmHg, or a history of oral antihypertensive medication	Cross-sectional study	2 092	1 066	15
SONG	Bengbu, Anhui Province	2018	SBP≥140 mmHg, DBP≥90 mmHg, or the subject reported with a medical history of antihypertensive medication	Cross-sectional study	1 777	433	14
WANG	Liaoning Province	2012	Blood pressure level of at least 140/90 mmHg, individuals who were on antihypertensive medications or a prior diagnosis of hypertension	Cross-sectional study	11 400	5 684	17
HUANG	Foshan, Fujian Province	2017	Prehypertension was defined as SBP 120‒139 mmHg and/or DBP 80‒89 mmHg, and hypertension was defined as SBP≥140 mmHg, DBP≥90 mmHg and/or a reported medical history of antihypertensive medication	Cross-sectional study	1 681	458	17
LEE	The Taiwan region	2022	Hypertension was defined as a self-reported history, SBP≥140 mmHg, or DBP≥90 mmHg during follow-up	Cohort study	21 466	3 157	16
LUO	Dalian, Liaoning Province	2011	Blood pressure≥140/90 mmHg and/or persons with confirmed hypertension and receiving treatment	Cross-sectional study	9 913	4 948	14

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