Journal of Shanghai Jiao Tong University (Medical Science) ›› 2023, Vol. 43 ›› Issue (4): 466-473.doi: 10.3969/j.issn.1674-8115.2023.04.009

• Evidence-based medicine • Previous Articles    

Meta analysis of correlation between lipid accumulation product and hypertension in Chinese adults

MA Zhuoran1,2(), YUAN Ancai2, JIANG Huiru2, CHEN Xiaoyu3, ZHANG Wei2(), PU Jun2()   

  1. 1.School of Public Health, Bengbu Medical College, Bengbu 233030, China
    2.Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
    3.Center for Clinical Investigation, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2022-10-25 Accepted:2023-03-14 Online:2023-04-28 Published:2023-04-28
  • Contact: ZHANG Wei,PU Jun E-mail:asd3ggb@qq.com;zhangwei050080@renji.com;pujun310@hotmail.com
  • Supported by:
    Key Research Center Construction Project of Shanghai(22DZ2292400);Emerging Interdisciplinary Research Project of Shanghai Municipal Health Commission(2022JC013);Key Clinical Specialty of Shanghai Municipal Health Commission(SHSLCZDZK06204)

Abstract:

Objective ·To explore the correlation between lipid accumulation product (LAP) and hypertension in Chinese adults. Methods ·By searching the English literature databases including PubMed and Web of Science, and the Chinese literature databases including CNKI and WanFang Data Knowledge Service Platform database, the earliest literature related to LAP and hypertension in Chinese adults that could be retrieved from databases establishment to August 2022. Two researchers independently screened all the retrieved literature according to the inclusion and exclusion criteria, and used the diagnostic research scale developed by Joanna Briggs Institute (JBI) to evaluate the literature quality of the selection, comparability, exposure evaluation and results of the study population. The sample size, gender, sensitivity, specificity and other information were extracted from the included literature. Stata 16.0 software was used for meta-analysis. Results ·A total of 6 articles were included, including five in English and one in Chinese. The JBI bias scores of the included articles ranged from 14 to 17 points, all of which were greater than 70% of the total score, so the biases could be considered small. The total number of samples included was 48 329, including 15 746 patients with hypertension. The results of meta-analysis showed that in the total population, the sensitivity of LAP in predicting hypertension was 0.50 (95%CI 0.35?0.64), and the specificity was 0.78 (95%CI 0.66?0.86); In women, the sensitivity was 0.48 (95%CI 0.32?0.64), and the specificity was 0.77 (95%CI 0.64?0.86); In males, the sensitivity was 0.56 (95%CI 0.39?0.72), and the specificity was 0.64 (95%CI 0.49?0.77). The area under the summary receiver operator characteristic curve (SROC curve) of the total population included was 0.70 (95%CI 0.66?0.74), indicating that there was a certain correlation between LAP and hypertension. Conclusion ·In Chinese adult population, LAP is associated with hypertension to a certain extent.

Key words: lipid accumulation product (LAP), hypertension, adult, Chinese, meta-analysis

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