Abstract:

Objective ·To explore the latent profiles of resilience among young and middle-aged patients with gastrointestinal cancer undergoing chemotherapy, and analyze the factors associated with these profiles. Methods ·From October 2024 to August 2025, a purposive sampling method was adopted to enroll young and middle-aged patients (18‒59 years old) with gastrointestinal cancer who received standardized chemotherapy in the Department of Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine. A cross-sectional survey was conducted using the General Information Questionnaire, Resilience Scale, Emotion Regulation Questionnaire, Social Support Rating Scale, and Hospital Anxiety and Depression Scale. Mplus 8.3 software was used for latent profile analysis. With each item score of resilience as the indicator variable, the latent categories of resilience in young and middle-aged patients with gastrointestinal cancer undergoing chemotherapy were identified. Subsequently, multivariate Logistic regression analysis was performed to identify factors associated with the latent profiles, with the profile category as the dependent variable. Results ·A total of 393 valid patients were included, and the total resilience score of patients was 65.72±13.54. The model fitting results showed that the three-profile model was optimal. According to the characteristics of item scores, the three profiles were named as the passive vulnerability group (21.4%), stable adaptation group (51.1%), and active growth group (27.5%). Multivariate Logistic regression analysis revealed that, with the active growth group as the reference, patients who were male, had no religious belief, had a monthly income of less than 3 000 yuan, had a higher depression level, and obtained lower scores of subjective support and cognitive reappraisal were more likely to be classified into the passive vulnerability group. Patients who had no religious belief, had a monthly income of less than 10 000 yuan, and had lower scores of subjective support and cognitive reappraisal were more likely to be classified into the stable adaptation group. Conclusion ·Resilience among young and middle-aged patients with gastrointestinal cancer undergoing chemotherapy exhibits heterogeneity and can be divided into three categories: the passive vulnerable group, stable adaptive group, and active growth group. Patients who are male, have no religious belief, have a lower monthly income, have a higher depression level, have lower subjective support, and use cognitive reappraisal strategies less frequently tend to have lower resilience levels.

Key words: gastrointestinal cancer, resilience, young and middle-aged adult, chemotherapy, latent profile analysis