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Advances of effects of chronic low-grade inflammation on pathophysiology of polycystic ovary syndrome

LIN Zi-jun, TAO Tao, LIU Wei   

  1. Department of Endocrinology and Metabolic Diseases, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2013-12-28 Published:2014-01-02
  • Supported by:

    National Natural Science Foundation of China, 81270875

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Abstract:

Inflammation is closely related to the occurrence and development of metabolic syndrome. Polycystic ovary syndrome (PCOS) is the most common endocrinology
metabolic disease in reproductive women. Recent studies showed that PCOS is related to  the situation of chronic low-grade inflammation, which is highly
correlated to long-term complications of PCOS. However, the new evidences indicated that chronic persistent inflammation may take part in the early
development of pathophysiology of PCOS, such as interaction between chronic inflammation and hyperandrogenism and insulin resistence. With the early
detection and treatment of chronic low-grade inflammation of PCOS, it can be a new direction of pathogenesis and treatment of PCOS.

Key words: polycystic ovary syndrome, chronic low-grade inflammation, insulin resistance, hyperandrogenism, anti-inflammation therapy