• Original article (Clinical research) • Previous Articles     Next Articles

Relationship between expression of estrogen receptor α isoforms in endometrial cancer and its prognosis

OUYANG Yi-qin1, YANG Min2, LI Li1, LI Huai-fang1, TONG Xiao-wen1, GAO Tian1, ZHU Xin-xian1   

  1. 1.Depatment of  Gynecology and  Obstetrics, Tongji Hospital, Tongji University, Shanghai 200065, China; 2.Tongji University School of Medicine, Shanghai 200092, China
  • Online:2014-03-28 Published:2014-04-02
  • Supported by:

    National Natural Science Foundation of China, 81101967


Objective To explore the impacts of different estrogen receptor α (ERα) isoforms on biological effects of endometrial cancer (EC) and the prognosis of EC patients. Methods A retrospective study was carried out for 116 endometrial cancer patients and an analysis of relationship between the ERα isoform expression pattern of EC tissue and the clinicopathological data and prognosis was performed. Patients' RNAs were extracted from paraffin sections and Real-Time PCR was used to analyze the gene's expression level. Results ERα expression level was related to the tumor differentiation grade (rs=-0.214, Spearman's test), lymphonode metastases (rs=-0.186, Spearman's test), and FIGO stage (rs=-0.221, Spearman's test). ERα exon 7 skipping isoform (Δ7) was the most commonly detected isoform.  Δ7 was related to the tumor differentiation and FIGO stage and its high expression level was found relating to the preferred surviva (diseasespecific survival P=0.026, disease-progression free survival P=0.038). Conclusion ERαΔ7 is an independent prognosis factor of endometrial cancer and its expression level affects the prognosis of endometrial cancer patients.

Key words: endometrial carcinoma, estrogen receptor, prognosis