Abstract:

Endometrial cancer is a common gynecological malignant tumor which is induced both by genes and environment. The gene effects are prominent. Protooncogenes, tumor suppressor genes, estrogen metabolism genes, and estrogen and progesterone receptor gene mutations and polymorphisms could increase the risk of endometrial cancer. Exploration of gene factors of endometrial cancer helps predicting the onset of the endometrial cancer and may provide appropriate health guidance for women. Currently several genes have been found to be associated with endometrial cancer. The research progress of relevant genes of endometrial cancer is reviewed in this paper.

Key words: endometrial cancer, gene, single nucleotide polymorphisms