Abstract:

Objective To systematically evaluate the annual progression rate of each subtype of impaired glucose tolerance (IGR) during the course of developing towards diabetes and provide the objective proof for early screening and intervention of IGT. Methods Random and non-random control studies relevant to impaired fasting glucose (IFG), impaired glucose tolerance (IGT), isolated-impaired fasting glucose (I-IFG), isolated-impaired glucose tolerance (I-IGT), and combined glucose intolerance (CGI) were retrieved form the PubMed, EMbase, Science Citation Index databases, Cochrane Library, CBMdisc, and CNKI by computer and manual retrievals. Papers were screened according to the inclusion and exclusion criteria. Data was abstracted and the methodology quality was assessed. The RevMan 5.0 software was adopted to conduct the meta-analysis. Results Thirteen studies were included. The results of meta-analysis showed that the annual progression rate during the course of developing towards diabetes of the IGT group, IFG group, I-IFG group, I-IGT group, and CGI group was 7.18 (95%CI 3.70-13.94，P<0.000 01), 4.29 (95%CI 2.29-8.03, P<0.000 01), 5.94 (95%CI 3.87-9.14, P<0.00001), 9.55 (95%CI 6.55-13.94, P<0.000 01), and 12.96 (95%CI 7.09-22.69, P<0.000 01) times of that of the control group. Conclusion The annual progression rate of each subtypes of IGR during the course of developing towards diabetes is 5%-10% and the progression rates of IGT and I-IGT are slightly higher than those of IFG and I-IFG. With the extension of observation time, the annual progression rate of each subtype gradually decreases.

Key words: impaired glucose tolerance, annual progression rate, meta-analysis