Abstract:

The treatment of pancreatic carcinoma is still a challenge. Surgical removal is the only chance to cure pancreatic cancer. The risk of recurrence and metastasis remains high even for patients who have undergone radical dissection. Therefore, adjuvant therapy after surgery is crucial. For patients whose tumors are considered borderline resectable, neoadjuvant therapy before surgery maybe a good choice. Chemotherapy, alone or in combination with radiation, is the major treatment for patients with advanced pancreatic carcinoma, but the outcome is not ideal. The targeted therapy shows promising future, but the therapeutic effect is unsatisfactory by far. This paper reviews clinical studies on the treatment of pancreatic cancer, so as to explore better therapy models.

Key words: pancreatic cancer, surgery, chemoradiotherapy, chemotherapy