Abstract:

Chemokines are a family of small cytokines secreted by immune cells, which act as a chemoattractant to guide the migration of immune cells. It has been reported that CCL19 (chemokine C-C motif ligand 19) and its receptor CCR7 (a seven transmembrane protein) are expressed in dendritic cells, CD4+ and CD8+T cells and variety of tumor cells. Recently, more attention has been focused on the antitumor effect of CCL19 and its receptor CCR7, which has been well-documented in the literature and was vital to attracting dendritic cells, infiltration of tumors by CD4+ and CD8+T cells, mediating immune cells to release cytokines, inhibiting the proliferation, invasion, and migration of tumors, and assisting the treatment of tumors. Further studies on CCL19 and CCR7 are helpful for developing new treatments of tumors and gene vaccines. This paper reviews the role of CCL19 the immune cell mediated antitumor therapy.

Key words: chemokine CCL19, receptor CCR7, dendritic cells, tumor