Objective To explore the correlation between three polymorphisms (T241M, A4541G, and A17893G) of DNA repair gene XRCC3 and susceptibility to ovarian cancer and conduct meta-analysis. Methods Case-control studies on the relationship between polymorphisms of gene XRCC3 (T241M, A4541G, and A17893G) and the incidence of ovarian cancer were collected by comprehensively retrieving relevant literature from databases. Unqualified papers were removed according to the quality evaluation criteria for selecting literature. Values of OR and 95％CI were calculated by Stata 10.0 and data of research results were merged. The correlation of different genotypes and polymorphisms of gene XRCC3 and the susceptibility to ovarian cancer was compared. The consistence and publication bias were evaluated. Results The meta-analysis was conducted for 6 studies, including the ovarian cancer group (n=5 529) and control group (n=8 350) which met the H-W genetic equilibrium. Results of meta-analysis showed that the differences of frequency distribution of allelotypes T and M of XRCC3 T241M, A and G of XRCC3 A4541G, and A and G of XRCC3 A17893G of the ovarian cancer group and control group were not statistically significant (P>0.05). The polymorphisms of XRCC3 T241M were not significantly correlated with the incidence of ovarian cancer (P>0.05). The polymorphisms of XRCC3 A4541G were correlated with the incidence of

ovarian cancer and genotypes GG/AA, GG/AG+AA, and AG/AA were correlated with the incidence of ovarian cancer (P<0.05; OR=0.71, 95%CI=0.56-0.90; OR=0.67, 95%CI=0.53-0.87; OR=1.06, 95%CI=1.00-1.14). The polymorphisms of XRCC3 A17893G were correlated with the incidence of ovarian cancer and genotypes GG+AG/AA and GG/AG+AA were correlated with the incidence of ovarian cancer (P<0.05; OR=0.81, 95%CI=0.79-0.84; OR=1.14, 95%CI=1.02-1.28). Conclusion Polymorphisms of XRCC3 A4541G and A17893G are correlated with the incidence of ovarian cancer.