›› 2015, Vol. 35 ›› Issue (10): 1468-.doi: 10.3969/j.issn.1674-8115.2015.10.008

Previous Articles     Next Articles

Effects of the interaction of childhood trauma and polymorphism of 5-HTT transporter on the development of borderline personality disorder

WANG Lan-lan, WANG Zhen, YU Shun-ying, QIU Jian-yin, ZHANG Ran, ZHANG Min, YUAN Cheng-mei,   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Nature Science Foundation of China， 81000591； Foundation of Fogarty International Center, National Institutes of Health, 81000591

PDF (PC)

1382

Abstract:

ObjectiveTo investigate the effects of childhood trauma, polymorphism of 5-hydroxytryptamine transporter (5-HTT), and their interaction on the development of borderline personality disorder (BPD).MethodsThe case-control study was conducted for 107 BPD patients, 91 non-BPD patients (schizophrenia and bipolar disorder were excluded), as well as 112 healthy controls. Clinical characteristics and the exposure of childhood trauma of them were investigated by questionnaires of general situation and childhood trauma and Revised Diagnostic Interview for Borderlines (DIB-R). Genotypes of 5-HTT were detected by PCR.ResultsCompared with the healthy control group, negative exposure experience of childhood trauma of the BPD group and non-BPD group was significant (P<0.05). The difference between the BPD group and non-BPD group was not statistically significant (P>0.05). Compared with the healthy control group and non-BPD group, the frequency of allele 5-HTTLPR (S’) (92.5%) of the BPD group remarkably increased (P<0.05) and the frequency of genotype 5-HTTLPR (S’/S’) (85.0%) was remarkably higher than that of the non-BPD group (P<0.05). The differences of the frequency of allele 5-HTTLPR and distribution of genotypes between the non-BPD group and healthy control group were not statistically significant (P>0.05). For exposure to any types of trauma, physical abuse, and emotional abuse, the incidence of BPD of patients carrying 5-HTTLPR (S’/S’) was significantly higher than that of patients carrying 5-HTTLPR (L’/L’) and 5-HTTLPR (L’/S’)(P<0.05).ConclusionChildhood trauma and allele 5-HTTLPR (S’) may be important factors that affect the incidence of BPD.

Key words:

font-family: 宋体, mso-spacerun: 'yes', mso-ascii-font-family: Calibri, mso-hansi-font-family: Calibri, mso-bidi-font-family: 'Times New Roman', mso-font-kerning: 1.0000pt">borderline personality disorder, childhood trauma, 5-HTT polymorphismsfont-family: 宋体, mso-spacerun: 'yes', mso-ascii-font-family: Calibri, mso-hansi-font-family: Calibri, mso-bidi-font-family: 'Times New Roman', mso-font-kerning: 1.0000pt">