›› 2015, Vol. 35 ›› Issue (10): 1474-.doi: 10.3969/j.issn.1674-8115.2015.10.009

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Analysis of factors relevant to glucose and lipid metabolism of patients with bipolar disorder at manic phase

XING Meng-juan1, HONG Wu1, HUANG Jia1, WANG Zuo-wei1,2, SU You-song1, FANG Yi-ru1   

  1. 1.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China; 2.Shanghai Hongkou District Mental Health Center, Shanghai200083, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Key Technology Research and Development Program of the Ministry of Science and Technology of China in the “12th Five-year Plan”, 2012BAI01B04； Project of Key Laboratory on Holergasia of Shanghai Mental Health Center， 13dz2260500； National Key Clinical Disciplines at Shanghai Mental Health Center， OMA-MH 2011-873； National Natural Science Foundation of China， 81201056， 81301159； International Cooperation Project of Shanghai Mental Health Center, 2013-YJGJ-06

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Abstract:

ObjectiveTo investigate the glucose and lipid metabolism of patients with bipolar disorder and relevant influencing factors. MethodsA total of 3 906 patients with bipolar disorder were screened by the questionnaire of Bipolar Mannia Pathway Survey (BIPAS) and 2 229 of them were enrolled.ResultsThe levels of glucose and lipid of patients were significantly abnormal and the levels of triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were correlated with the gender (P<0.05). The differences of levels of TG, LDL, and fasting blood glucose (FBG) of patients at different clinical phases (first episode phase, relapse phase, and stationary phase) were statistically significant (P<0.05). The differences of the TG level of patients who underwent different drug therapies (mood stabilizers combined with antipsychotics and stabilizers combined with non-antipsychotics) were statistically significant (P<0.05). The differences of the levels of glucose and lipid of patients with different course of disease, types of first episode, and number of attacks were statistically significant (P<0.05).ConclusionThe levels of glucose and lipid of patients with bipolar disorder are significantly abnormal. The differences of levels of glucose and lipid correlate with the gender, clinical phase of bipolar disorder, treatment, course of disease, type of first episode, and number of attacks.

Key words: bipolar disorder, mania, metabolic disorder