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Comparative study on evaluating brain perfusion of patients with ischemic stroke by intravoxel incoherent motion perfusion imaging and three-dimension arterial spin labeling imaging

ZU Jin-yan1,2, SUO Shi-teng1,2, ZHOU Zi-en1,2, CAI Jin1,2, LI Jun1,2, ZOU Ai-hua1,2, ZHU Wan-qiu3, CHEN Zeng-ai1,2, LI Lei1,2, XU Jian-rong1,2   

  1. 1.Department of Radiology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Shanghai 201112, China； 2.Department of Radiology， Renji Hospital， Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China； 3.Department of Radiology, First Affiliated Hospital of Anhui Medical University， Hefei 230022, China
  • Online:2015-12-28 Published:2016-01-21
  • Supported by:

    Biomedical Engineering Cross Research Foundation of  Shanghai Jiao Tong University， YG2014MS50； Foundation of Shanghai Municipal Commission of Health and Family Planning， 201540231； Scientific Research Initial Foundation of Renji Hospital South Campus， Shanghai Jiao Tong University School of Medicine, 2014QDM12

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Abstract:

Objective  To compare and analyze the clinical application value of intravoxel incoherent motion perfusion imaging MRI (IVIM-MRI) and three-dimension arterial spin labeling (3D-ASL) imaging for evaluating changes of brain perfusion of patients with ischemic stroke. Methods  A total of 46 patients with ischemic stroke underwent routine MRI with DWI, 3D-ASI, and IVIM. Stroke areas indicated by DWI and contralateral normal areas were selected as regions of interest and changes of bilateral local cerebral blood flow (CBF) were measured by 3D-ASL. Parameters measured by IVIM were apparent diffusion coefficient (ADC), diffusion coefficient of pure diffusion (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f). Paired t test was performed for stroke areas and contralateral areas. The relative values of all parameters were also calculated (r=stroke area/contralateral area). Spearman correlation analysis was performed for changes of relative values (rADC, rf, rD*, and rD) of parameters of IVIM and rCBF. Results  The CBFASL of stroke areas was lower than that of contralateral areas and the difference was significant (P<0.05). The differences of ADC, f, and D* between stroke areas and contralateral areas were significant (P<0.05). The D* of stroke areas was lower than that of contralateral areas and the difference was not statistically significant (P<0.05). Except rD*, the differences between rADC, rD, and rf of stroke areas and rCBFASL were statistically significant (P<0.05). Conclusion  The results of IVIM-MRI and 3D-ASL for the diagnosis of changes of brain perfusion of patients with ischemic stroke are consistent, which can be used for evaluating changes of brain perfusion after the incidence of ischemic stroke and are helpful for clinical diagnosis and treatment.

Key words: arterial spin labeling, cerebral blood flow, magnetic resonance imaging, intravoxel incoherent motion imaging