Abstract:

Objective To investigate the effects of serum 25(OH)D3 and lipid levels on the gestational diabetes mellitus (GDM). Methods Pregnant women who underwent prenatal examinations were enrolled and divided into the normal pregnancy group (control group, n=6 796) and GDM group (n=977). Serum 25(OH)D3, total cholesterol (TCh), triglyceride (TAG), high density lipoprotein cholesterol (HDL), and low density lipoprotein (LDL) levels of two groups at the second trimester of pregnancy (12-16 weeks) were detected. The logistic regression analysis was adopted to evaluate the effects of 25(OH)D3 and lipid levels on the pathogenesis of GDM. Results 25(OH)D3 and HDL levels of the GDM group were lower than those of the control group, while TAG, TCh, and LDL levels were higher than those of the control group. Logistic regression analysis showed that all indexes were relevant to the pathogenesis of GDM except LDL. TAG (OR=1.54) and TCh (OR=1.63) were risk factors of GDM, while 25(OH)D3 (OR=0.995) and HDL (OR=0.392) were protective factors of GDM. Conclusion Serum 25(OH)D3 and lipid levels at the second trimester play an important role in the pathogenesis of GDM. TAG and TCh are risk factors of GDM, while 25(OH)D3 and HDL are protective factors of GDM. Therefore, it can be attempted to reduce the incidence of GDM by the combination therapy of lowering lipids and glucose.

Key words: gestational diabetes mellitus, 25 (OH) D3；lipid, risk factor