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Effects of cisplatin-alginate conjugate liposomes in cervical cancer-bearing nude mice

GAO Hua1, WANG Yun-fei2, WANG Wen-jing1, ZHANG Mei-ying1, LI Qing1, DING Ying1, DI Wen1   

  1. 1.Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2.Department of Gynecology, Affiliated Hospital of Jining Medical University, Jining 272029, China
  • Online:2017-05-28 Published:2017-05-31
  • Supported by:

    Foundation of Shanghai Municipal Commission of Health and Family Planning, 20134205

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Abstract:

Objective · To establish human cervical cancer xenografts in nude mice and investigate the antitumor therapeutic effects and safety of EGF modified cisplatin-alginate conjugate liposomes. Methods · Cervical cancer-bearing mouse model was established by subcutaneously injecting Hela cells in nude mice. General state and xenograft growth of the mice were observed. Tumor volumes, tumor weights, and the body weights of mice during the treatment were recorded and analyzed. The expression levels of EGFR in xenografts were detected by immunohistochemistry. Results · ① EGFR was highly expressed in the xenografts. ② CS-EGF-Lip inhibited the tumor growth effectively (P=0.000). ③ The inhibition rates of tumor volume and tumor weight of CS-EGF-Lip were 80.22% and 58.60% respectively, which were better than those of cisplatin (P=0.000). ④ CS-EGF-Lip had minimal influence on body weight in mice (P=0.000). Conclusion · CS-EGF-Lip has more effective antitumor effects than cisplatin in cervical cancer-bearing mice, which can inhibit tumor growth of solid tumors with enhanced efficacy and safety.

Key words: nanoparticles, cervical cancer, tumor growth