›› 2019, Vol. 39 ›› Issue (6): 613-.doi: 10.3969/j.issn.1674-8115.2019.06.009

• Original article (Clinical research) • Previous Articles     Next Articles

Automatic layer segmentation of optical coherence tomography images in retinal vascular diseases

XU Yu-peng1*, DU Yu-chen1, 2*, CHEN Feng-e1   

  1. 1. Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Key Laboratory of Fundus Disease, Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; 2. Department of Automation, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
  • Online:2019-06-28 Published:2019-07-26
  • Supported by:
    National Key R&D Plan on Precision Medicine, 2016YFC0904800; Shanghai Sailing Program, 19YF1439300; “Translation Medicine Cross Research Fund” Project of Shanghai Jiao Tong University, ZH2018QNA24)。

Abstract: Objective · To explore the layer segmentation method of optical coherence tomography (OCT) images of retinal vascular diseases using an unsupervised learning method, and compare it with the built-in layering method of OCT machine. Methods · Standardized image acquisition was performed on OCT images 50 patients with myopic choroidal neovascularization (mCNV) and 20 patients with diabetic macular edema (DME). Standards were establishedmanual marking of hierarchical informationprofessional physicians. A retinal multi-layer segmentation method based on the minimization of interlayer energy was proposed, and the results were compared with those obtainedthe built-in layering method of OCT machine. The layering accuracy was verifiedthe unmarked boundary position error. Results · This segmentation method divided the retina of each patient into five layers: internal limiting membrane, lower layer of nerve fiber layer, upper layer of outer nuclear layer, upper layer of ellipsoid zone and Bruchs membrane. The average segmentation error in the overall data set was (4.831±7.015) μm. The error of mCNV group and DME group were (4.839±16.819) μm and (5.048±9.986) μm, respectively, both of which were lower than the automatic measurement results of OCT machine [(13.638±58.024) μm and (14.796±45.342) μm, respectively]. The accuracy of this method at each layer was higher than that of the automatic measurement. Conclusion · This multi-layer segmentation method can be used for segmentation of different types of retinal vascular diseases, and the results are significantly better than those obtainedthe built-in method in OCT machine. It can be extended for layer segmentation of other retinal vascular diseases.

Key words: retinal vascular diseases, optical coherence tomography (OCT), automatic analysis algorithm, machine learning, computer vision

CLC Number: