›› 2020, Vol. 40 ›› Issue (3): 333-.doi: 10.3969/j.issn.1674-8115.2020.03.009

• Original article (Clinical research) • Previous Articles     Next Articles

Analysis on sleep quality and characteristics of depression patients with different degrees of anxiety

TANG Ye-zhou, SHI Yi-fan, HUANG Yu-xin, ZHAO Ya-juan, FU Hao, HUANG Jia, WANG Yong   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2020-03-28 Published:2020-04-09
  • Supported by:
    National Key Research and Development Program of China (2016YFC1307100);National Natural Science Foundation of China(81771465);Scientific Research Program of Shanghai Municipal Commission of Health and Family Planning (201640107);Medical Engineering (Science) Cross Research Foundation of Shanghai Jiao Tong University (YG2016MS39);Municipal Hospital Clinical Research Cultivation Project of Shanghai Shenkang Hospital Development Center (SHDC12018X24).

Abstract: Objective · To compare the sleep quality of depressive patients with and without anxiety symptoms. Methods · Hamilton Depression Scale-17 (HAMD-17), Hamilton Anxiety Scale (HAMA) and Pittsburgh Sleep Quality Index Scale (PSQI) were used to assess the level of patients depression, anxiety and sleep quality. The HAMA scores of patients ranged 0 to 6 were in the anxiety-free group, 7 to 13 in the anxiety-prone group, and 14 or more in the anxiety group. Results · The PSQI scores of the group with anxiety were higher than those of anxiety-prone group and anxiety-free group (both P0.000). Partial correlation analysis showed that, after controlling HAMD-17 scores, the correlation between HAMA scores and PSQI scores reduced gradually with the increase of anxiety level. The multiple linear regression analysis showed that sleep disorder was still an independent risk factor for depression after controlling HAMA score. Sleep latency, sleep time, hypnotics and daytime dysfunction were independent predictive factors of HAMD-17 score (all PConclusion · In patients with depressive disorder, the severity of sleep disorder increases with the increase of anxiety level. In the case of comorbidity anxiety, sleep disorder is still an independent risk factor for depressive disorder, and the relationship between depressive symptoms and sleep disorder indicators of different dimensions suggests that sleep disorder plays a comprehensive role in the pathogenesis of depressive disorder.

Key words: sleep quality, depression, anxiety, Hamilton Depression Scale-17, Hamilton Anxiety Scale, Pittsburgh Sleep Quality Index Scale