Functions of SNARE complex in glial cells and its relationship with the development of depressive disorder

doi:10.3969/j.issn.1674-8115.2024.05.015

Abstract

Abstract:

Depression is a common cause of human disability and death. Some patients are not sensitive to antidepressants, and also the recurrence rate is very high. Unfortunately, there are many problems with existing antidepressants. So, it is urgent to find a new antidepressant aiming at multiple targets. Recently, researchers have found that soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is closely related to the progression of depression. This review discusses the potential mechanisms of the SNARE complex in glial cells, and hopes to contribute to the understanding of depression and provide new ideas for clinical development of novel antidepressant drugs.

Key words: depression, soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex, glia cells

CLC Number:

R749.4

GU Juanhua, JIAO Yang, LU Lin, WANG Linlin. Functions of SNARE complex in glial cells and its relationship with the development of depressive disorder[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(5): 653-657.

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