Research progress on the neural circuit of pain emotion mediated by amygdala

doi:10.3969/j.issn.1674-8115.2023.10.012

Abstract

Abstract:

The occurrence of pain emotion is closely related to the functional and structural changes of specific central nervous circuit. When pain is accompanied by depression, anxiety, pain aversion memory and other emotional states, it activates or inhibits different neural circuits. The amygdala (AMY) of the limbic system participates in the regulation of pain, anxiety, depression, aversive memory and other emotions, and has extensive connections with brain nuclei related to pain and emotion, jointly regulating pain, anxiety, depression, aversive memory and other responses. This article summarizes the main circuits related to pain emotions mediated by AMY. It is concluded that the neural circuits related to depression include central amygdala → parafascicular nucleus of thalamus (CeA ^GABA → PF ^Glu), dorsal raphe nucleus → central amygdala (DRN ^5-HT → CeA ^SOM), central amygdala → ventrolateral periaqueductal gray (CeA ^GABA → vlPAG ^GABA). Nerve circuits related to anxiety include ventral tegmental area → central amygdala (VTA→CeA^DA), locus coeruleus → basolateral amygdala (LC^NE→BLA). The neural circuit related to pain aversion memory is lateral parabrachial nucleus → central amygdala (lPBN ^CGRP→CeA ^CGRP). Among them, activating the CeA^GABA→PF ^Glu circuit can lead to depression accompanied by pain, activating the CeA ^GABA→vlPAG ^GABA circuit can alleviate pain sensitivity caused by depression, and activating the DRN ^5-HT→CeA ^SOM circuit can alleviate pain perception and depressive emotions; activating the VTA→CeA ^DA loop can alleviate pain sensitivity and anxiety like behavior, inhibiting LC ^NE→BLA loop can alleviate anxiety caused by pain; activating the lPBN ^CGRP→CeA ^CGRP loop can generate pain aversion memory.

Key words: pain emotion, amygdala (AMY), nerve circuit, anxiety, depression, aversive memory

CLC Number:

R338.3

MA CUI, YE Yujuan, YAN Xingke. Research progress on the neural circuit of pain emotion mediated by amygdala[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(10): 1304-1310.

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