JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (10): 1384-1388.doi: 10.3969/j.issn.1674-8115.2021.10.018

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Research progress in the mechanism of helper T cell 17 and regulatory T cell in depression

Rui-xue YUAN(), Ying-mei FU, Shun-ying YU()   

  1. Genetic Research Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine Shanghai 200030, China
  • Online:2021-10-28 Published:2021-08-09
  • Contact: Shun-ying YU;
  • Supported by:
    Natural Science Foundation of Shanghai(20ZR1448400)


Depression is a global mental illness with increasing incidence, heavy disease burden and complicated pathogenesis. In recent years, based on the inflammatory hypothesis of depression, studies have demonstrated that the occurrence and development of the disease is closely related to the immune imbalance mediated by helper T cell 17 (Th17) and regulatory T cell (Treg). Moreover, reports have shown that both Th17 and Treg can be regulated by gut microbiome which involves in the pathogenesis of depression through the brain-gut axis mechanism. In addition, basic and clinical researches reveal that the levels of Th17 and Treg in peripheral blood are capable of affecting the efficacy of antidepressants. Therefore, this article combines the studies of gut microbiome to briefly review the research progress in the effect of Th17 and Treg on the pathogenesis of depression and the treatment of antidepressants.

Key words: depression, helper T cell 17 (Th17), regulatory T cell (Treg), gut microbiome

CLC Number: