Research advances in mechanisms of super-enhancers-driven oncogenesis

doi:10.3969/j.issn.1674-8115.2021.10.017

Abstract

Abstract:

Transcriptional dysregulation is one of the core mechanisms of tumorigenesis. Recently, the term "super-enhancer" has been introduced to describe a hyperactive regulatory domain which comprises a complex array of sequence elements that are critical to maintain the identity of tumor cells and promot oncogenic transcription. Super-enhancers are highly occupied by transcriptional factors, co-activators and histone modifications. Cooperative interactions amongst these components make super-enhancers have higher transcriptional activity than typical enhancers. This article reviews basic structural and functional characteristics of super-enhancers, formation of the phase-separated condensates, the mechanisms of super-enhancer-driven oncogenesis, and the formation and significance of topologically associating domains.

Key words: super-enhancers (SEs), transcriptional regulation, cancer, phase-separated condensate, topologically associating domain

CLC Number:

R394.3

Peng GU, Xing SUN. Research advances in mechanisms of super-enhancers-driven oncogenesis[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(10): 1378-1383.

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