JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (4): 554-558.doi: 10.3969/j.issn.1674-8115.2021.04.024

• Review • Previous Articles    

Research advances in stem cell-based therapies for acute respiratory distress syndrome

Jia-yang YAN(), Yun FENG, Jie-ming QU()   

  1. Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2020-03-10 Online:2021-04-28 Published:2021-05-14
  • Contact: Jie-ming QU;
  • Supported by:
    Innovative Research Team of High-Level Local Universities in Shanghai(SSMU-ZDCX20181001)


Acute respiratory distress syndrome (ARDS) is caused by various factors which damage pulmonary alveolar capillary barrier. The morbidity and mortality are high, but there are no effective and specific treatments. A large number of studies have identified that stem cells can ameliorate lung injury in various ways. As novel biological therapy methods, stem cell-based therapies have achieved good results in ARDS preclinical models while clinical trials have shown that the therapeutic efficacy is unsatisfactory. Accordingly, several strategies have been explored to strengthen the therapeutic potential of stem cells. This article reviews research advances in stem cell-based therapies for ARDS and strategies to enhance the therapeutic potential of stem cells.

Key words: acute respiratory distress syndrome (ARDS), stem cell, therapy

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