›› 2009, Vol. 29 ›› Issue (10): 1205-.

• Original article (Clinical research) • Previous Articles     Next Articles

Four-year follow-up study of changes in prescriptions of antidepressants for inpatients with psychosis

CHEN Jun1, WANG Zu-cheng1, WANG Min2, WANG Yong1, WU Zhi-guo1, HUANG Jia1, LI Ze-zhi1, SU You-song1, FANG Yi-ru1   

  1. 1. Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai 200030, China;2. Jiaozuo Ankang Hospital, Jiaozuo 454100, China
  • Online:2009-10-25 Published:2009-10-26
  • Supported by:

    10th “Five-year Plan” of National Key Technologies R&D Program, 2004BA720A21-02;National High-tech R&D Program, “863” Program, 2006AA02Z430;“Climbing Mountain Action Plan” Program of Shanghai, 064119533;Shanghai Jiaotong University School of Medicine Natural Science Foundation, 09XJ21024


Objective To investigate the changes in the prescriptions of antidepressants for inpatients with psychosis from 2005 to 2008. Methods The prescriptions of antidepressants for all the inpatients with psychosis in Shanghai Mental Health Center were investigated by one day survey on each June 1st from 2005 to 2008. The most common diseases treated with antidepressants, the most commonly used antidepressants, the average dosage of antidepressants and the combination use of antidepressants were analysed. Results The most common diseases treated with antidepressants were affective disorder, schizophrenia and neurosis. The prescription rate of tricyclic antidepressants declined year by year, and that of selective serotonin reuptake inhibitors (SSRIs) fluctuated moderately, while that of antidepressants of newer generation with the other transmitter mechanisms such as venlafaxine, mitrazapine and trazodone increased gradually. Single antidepressant prescription was common, while the combination use of antidepressants accounted for a small portion. Combination use of antidepressants with one psychotropics (antipsychotics, mood stabilizer, sedative hypnotics) was common, while with two were less frequently occurred. Conclusion Prescriptions of antidepressants for patients with psychosis hospitalized in Shanghai Mental Health Center from 2005 to 2008 are relatively safe and reasonable. Antidepressants of newer generation have been widely used in clinics, and SSRIs have been serving as the major antidepressants.

Key words: antidepressants, prescriptions, inpatients, psychosis, time point survey

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