Abstract:

Helicobacter pylori (H.pylori) infection has been an established risk factor for gastric cancer identified by World Health Organization. H.pylori triggers chronic inflammation of gastric mucosa and induces host cells to release various cytokines, some of which might lead normal epithelial cells to transfer to gastric cancer. Expression of interleukins in gastric mucosa experiences significant changes after H.pylori infection. Interleukins play different roles in carcinogenesis and development of gastric cancer. This article briefly reviews the research advances of roles of interleukins in carcinogenesis and development of gastric cancer.

Key words: gastric cancer, interleukins, inflammation