›› 2010, Vol. 30 ›› Issue (6): 631-.

• Monographic report (Depressive disorder) • Previous Articles     Next Articles

Comparison study of cognitive function between treatment resistant depression and fist episode depression

CHEN Jun, WU Zhi-guo, WANG Yong, ZHANG Chen, HUANG Jia, LI Ze-zhi, SU You-song, YUAN Cheng-mei, HONG Wu, PENG Dai-hui, YI Zheng-hui, CAO Lan, HU Ying-yan, WANG Ling-xiao, FANG Yi-ru   

  1. Division of Mood Disorder, Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2010-06-25 Published:2010-06-28
  • Supported by:

    National Key Technologies R&D Program of “10th Five-Year Plan”, 2004BA720A21-02；Shanghai “Climbing Mountain Action Plan” Program, 064119533, 2006-2008；High-Tech Research and Development Program of China, “863” Program, 2006AA02Z430；Shanghai Jiaotong University School of Medicine Foundation, 09XJ21024

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Abstract:

Objective To investigate and compare the characteristics of cognitive function between treatment resistant depression (TRD) and first episode depression (FED). Methods Fifty-three patients with TRD (TRD group) and 21 patients with FED (FED group) were enrolled, and another 20 healthy volunteers were served as normal controls (control group). The disease severity was evaluated with Hamilton Depression Scale-17 (HAMD-17), Hamilton Anxiety Scale (HAMA), Self-Rating Depression Scale (SDS) and Clinical Global Impression-Severity Index (CGI-SI), the cognitive function was assessed with Wechsler Adult Intelligence Schedule (WAIS), Wechsler Memory Scale (WMS), Wisconsin Card Sorting Test (WCST) and Number Cancellation Test (NCT), and comparison was conducted among groups. Results The evaluation of disease severity revealed that the score of somatic anxiety factor of HAMD-17 in TRD group was significantly higher than that in FED group, while there was no significant difference in the scores of the other factors between these two groups. The assessment of cognitive function demonstrated that performance intelligence quotient, WMS memory quotient, long and short term memory, WCST number of categories completed, response administered, percent conceptual level responses, NCT correct number and score in TRD group and FED group were significantly lower than those in control group. However, WCST total time, error response time, number of perseverative errors and percent of perseverative errors in TRD group and FED group were significantly higher than those in control group. The scores of picture puzzle, space orientation, number order and vision regeneration in TRD group were significantly lower than those in FED group. Compared with the differences between FED group and control group, the differences between TRD group and control group in WCST error response time, number of perseverative errors, percent of perseverative errors, percent conceptual level responses, NCT correct number and score were more significant. Conclusion Clinical evaluation of disease severity can not reflect the characteristics of TRD. The impairment of imagination, ability to grasp the clues and hand-eye coordination, and working impairment on memory and attention are characterised in TRD.

Key words: treatment resistant depression, first episode depression, cognitive function, disease attributes