›› 2010, Vol. 30 ›› Issue (6): 717-.

• Original article (Clinical research) • Previous Articles     Next Articles

Correlation between single nucleotide polymorphisms of DCK and outcomes of acute myeloid leukemia treated by cytarabine

YANG Guan-qun, CHEN Fang-yuan, WAN Hai-xia, ZHONG Hua, WANG Hai-rong, ZHONG Ji-hua, CAI Jia-yi, OUYANG Ren-rong   

  1. Department of Hematology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China
  • Online:2010-06-25 Published:2010-06-28
  • Supported by:

    Shanghai Jiaotong University School of Medicine Foundation, 2008XJ015

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Abstract:

Objective To explore the relationship between single nucleotide polymorphisms (SNPs) of deoxycytidine kinase (DCK) and outcomes of acute myeloid leukemia (AML) treated by cytarabine (Ara-C). Methods Ligase detection reaction technique was employed to detect the genotype of 7 SNPs (SNP1-SNP7) from 126 patients with AML treated by Ara-C (AML group) and 100 healthy people (normal control group), and the genotype distribution and outcomes of patients with AML treated by Ara-C were analysed. Results There were significant differences in the allele distribution of SNP1 (rs2306744) and genotype distribution of SNP2 (rs12648166) of DCK between normal control group and AML group and between normal control group and Ara-C ineffective group (n=35) (P<0.05). In AML group, the CC genotype of SNP1, polymorphism genotype （AG+GG）of SNP2 and wild type  genotype of SNP3 (rs4694362) displayed a favorable response to chemotherapy. Conclusion SNPs of DCK gene may be one of the molecular markers to predict the outcomes of patients with AML treated by Ara-C.

Key words: acute myeloid leukaemia, cytarabine, deoxycytidine kinase, single nucleotide polymorphisms