Abstract:

Objective To investigate the expression of a panel of immunohistochemical markers in epithelioid angiomyolipoma (EAML) of the kidney, and explore its roles in the diagnosis, differential diagnosis and prognosis. Methods The expression of  vimentin, HMB45, Melan-A, AE1/AE3, EMA, SMA, ER, PR, CD68, CD10, CD34, CD117, S-100 protein, P53 and Ki-67 was detected in 13 cases of renal EAMLs by immunochemical EnVision method. Results All the 13 cases of tumor cells were positive for vimentin, SMA, HMB45, Melan-A and CD68, while negative for AE1/AE3, EMA, CD10, CD34, CD117, ER and PR. Three cases of tumor cells were positive for Ki-67 and P53, and 2 were positive for S-100 protein. Conclusion Immunohistochemical markers of SMA, HMB45, Melan-A, AE1/AE3 and EMA can be used as primary antibodies for diagnosis and differential diagnosis of EAML of the kidney. Ki-67 and P53 might be valuable indexes in prognosis prediction.

Key words: kidney neoplasm, epithelioid angiomyolipoma, immunohistochemistry, diagnosis