›› 2010, Vol. 30 ›› Issue (11): 1428-.doi: 10.3969/j.issn.1674-8115.2010.11.027

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Research progress of role of matrix metalloproteinase 7 in tumors

HUANG Yong, ZHENG Shu   

  1. Cancer Institute, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China
  • Online:2010-11-25 Published:2010-11-29
  • Supported by:

    National Natural Science Foundation of China, 30973382


Matrix metalloproteinase 7 (MMP7) plays an important role in tumorigenesis, tumor development and resistance to some anti-tumor medicine by degrading proteins of extracellular matrix and blocking fas/fasl apoptosis signal pathway. This paper discusses the mechanisms by which MMP7 contribute to carcinogenesis, and the research progress of MMP7 in tumor treatment.

Key words: matrix metalloproteinase 7, fas/fasl, apoptosis, neoplasm