›› 2010, Vol. 30 ›› Issue (12): 1569-.doi: 10.3969/j.issn.1674-8115.2010.12.028

• Review • Previous Articles     Next Articles

Research progress of role of statins in treatment of chronic obstractive pulmonary disease

ZHOU Jian, LING Mei-rong, DENG Xing-qi   

  1. Department of Emergency, Minhang Central Hospital, Shanghai Ruijin Hospital Group, Shanghai 201100, China
  • Online:2010-12-25 Published:2010-12-31


Chronic obstructive pulmonary disease (COPD) is characterized by progressive and minimally reversible airflow limitation with systemic inflammation, which can be prevented and treated. Statins reduce cholesterol levels by inhibiting 3-hydroxy-3-methlglutaryl coenzyme A(HMG-CoA) reductase, and have an established role in the treatment of cardiovascular diseases. Recent studies have revealed that statins have profound anti-inflammatory effects by reducing induction of matrix metalloproteinase, expression of cytokines and cell adhesion molecules, antioxidant state and C-reactive protein, which decreases lung function deterioration, morbidity and mortality in COPD.

Key words: statins, chronic obstractive pulmonary disease, therapy