Abstract:

Objective To observe the effects of carboprost on third stage of labor and postpartum hemorrhage in induced labor with scarred uterus. Methods One hundred women undergoing induced labor with scarred uterus were randomly divided into carboprost group and oxytocin group, with 50 women in each group. All women were orally administered 50 mg mifepristone twice a day for 2 d, and received injection of 100 mg acetamiprid in amniotic cavity on the third day. Women in carboprost group were orally administered 2 mg carboprost immediately after delivery, and those in oxytocin group received intrauterine injection of 20 IU oxytocin immediately after delivery. The duration of third stage of labor, volumes of postpartum hemorrhage (2 h and 24 h after delivery), rate of placenta residue, blood pressure (before delivery and 30 min, 1 h, 2 h and 24 h after delivery), pulse (before delivery and 30 min, 1 h, 2 h and 24 h after delivery) and occurrence of adverse effects were compared between two groups. Results The duration of third stage of labor and volumes of hemorrhage 2 h and 24 h after delivery in carboprost group were significantly lower than those in oxytocin group (P＜0.05), and the rate of placenta residue in carboprost group was significantly lower than that in oxytocin group (10% vs 26%, P＜0.05). There was no significant difference in the blood pressure and pulse at different time points between two groups (P>0.05). The prevalence of adverse effects in carboprost group was significantly higher than that in oxytocin group (34% vs 18%, P＜0.05). Conclusion Application of carboprost in induced labor with scarred uterus may reduce volume of postpartum hemorrhage, shorten duration of third stage of labor, and decrease rate of placenta residue.

Key words: Carboprost, scar uterus, induced labor, postpartum hemorrhage