Abstract:

Objective To investigate the curative effects of high-frequency loop electrosurgical excision procedure (LEEP) in treatment of cervical intraepithelial neoplasia (CIN) and cervical erosion. Methods The clinical data of 192 patients with CIN and cervical erosion undergoing LEEP were retrospectively analysed. According to different conditions in patients, shallow cervical ring excision (SRE),deep ring excision (DRE) or LEEP conization (LEEPC) were performed. The curative effects of LEEP in treatment of CIN and cervical erosion were evaluated, the effect of cervical regeneration was assessed, and the prevalence of complications was observed. Results There were 84, 68 and 40 patients undergoing SRE, DRE and LEEPC respectively. Six months after operation, the cure rate of CIN was 95.59% （65/68）, there was lesion residue after operation in 2 patients with CINⅡ and 1 patient with CINⅢ, and there was relapse in 1 patient with CINⅡ and 1 patient with CINⅢ. Three months after operation, the cure rate of cervical erosion was 94.35%（117/124）, and the cure rates of SRE, DRE and LEEPC were 96.43% （54/56）, 91.11% （41/45) and 95.65% （22/23) respectively. Three months after operation,the satisfaction rate of cervical regeneration from patients undergoing LEEP was 93.75% (180/192), and the satisfaction rates of cervical regeneration from patients undergoing SRE, DRE and LEEPC were 92.86％ (78/84), 95.66％ (65/68) and 92.5％ (37/40) respectively. Three months after operation, the prevalence of cervical mucous eversion was 4.17% （8/192）, among which SRE accounted for 7.14% (8/84), and DRE accounted for 2.94% (2/68).Carotid stenosis occurred in 7.5%(3/40) of patients undergoing LEEPC. Conclusion Corresponding LEEP should be adopted according to different cervical diseases, which may yield higher cure rate and better cervical regeneration. Individualized procedure should be carried out for the treatment of CIN and cervical erosion.

Key words: loop electrosurgical excision procedure, cervical intraepithelial neoplasia, cervical erosion, cervical regeneration