Bipolar disorder, as a major mental illness, has a high lifetime suicide attempt rate in patients, and suicidal behavior is most likely to occur during depressive episodes. Therefore, in-depth study of its mechanism is essential for prevention, early detection and intervention of suicide. With the development of magnetic resonance imaging (MRI) technology, it has been found that there are abnormalities in the brain structure and function in suicidal patients with bipolar disorder. This article reviews the studies on suicide in bipolar disorder patients by MRI from four aspects: structure, function, structure-function, and central metabolism and cerebral blood flow perfusion, and summarizes the suicide-related changes. This review focuses on distinguishing the brain MRI changes under different mood states and diverse definitions of suicide, aiming to provide reference for further exploration of the pathophysiological mechanism of suicide in bipolar disorder.
CHEN Jiaye, ZHANG Huifeng, LU Wenxian, PENG Daihui. Research progress of brain magnetic resonance imaging related to suicide in bipolar disorder patients. Journal of Shanghai Jiao Tong University (Medical Science)[J], 2023, 43(7): 939-944 doi:10.3969/j.issn.1674-8115.2023.07.017
CHEN Jiaye conceived the idea and drafted the original manuscript. ZHANG Huifeng and LU Wenxian participated in the reviewing and editing. The writing of the manuscript was guided by PENG Daihui. All the authors have read the last version of paper and consented for submission.
利益冲突声明
所有作者声明不存在利益冲突。
All authors disclose no relevant conflict of interests.
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