双相障碍患者自杀相关脑磁共振影像研究进展

doi:10.3969/j.issn.1674-8115.2023.07.017

上海交通大学学报（医学版） ›› 2023, Vol. 43 ›› Issue (7): 939-944.doi: 10.3969/j.issn.1674-8115.2023.07.017

• 综述 • 上一篇

双相障碍患者自杀相关脑磁共振影像研究进展

陈嘉烨(), 张慧凤, 卢文仙, 彭代辉()

上海交通大学医学院附属精神卫生中心心境障碍科，上海 200030

收稿日期:2022-12-14 接受日期:2023-05-18 出版日期:2023-07-28 发布日期:2023-07-28
通讯作者: 彭代辉 E-mail:momobean12@163.com;pdhsh@126.com
作者简介:陈嘉烨（1996—），女，博士生；电子信箱：momobean12@163.com。
基金资助:
上海市中央引导地方科技发展资金资助项目(YDZX20213100001003);上海市科学技术委员会面上项目(20ZR1448500)

Research progress of brain magnetic resonance imaging related to suicide in bipolar disorder patients

CHEN Jiaye(), ZHANG Huifeng, LU Wenxian, PENG Daihui()

Department of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Received:2022-12-14 Accepted:2023-05-18 Online:2023-07-28 Published:2023-07-28
Contact: PENG Daihui E-mail:momobean12@163.com;pdhsh@126.com
Supported by:
Central Funds Guiding Local Science and Technology Development of Shanghai(YDZX20213100001003);Foundation of Science and Technology Commission of Shanghai Municipality(20ZR1448500)

摘要/Abstract

摘要：

双相障碍是一种重性精神病，患者终生自杀未遂率高，且自杀行为大多发生在抑郁发作期间。因此，深入研究其机制对于预防和早期发现并干预自杀的发生至关重要。随着磁共振成像技术发展，双相障碍自杀患者的大脑结构和功能被发现存在异常。该文从结构改变、功能改变、结构-功能改变以及中枢代谢与脑血流灌注4个方面回顾以双相障碍患者为对象且应用磁共振成像技术进行研究的文献，总结自杀相关脑部影像学改变；侧重区分不同情绪发作状态下以及不同自杀定义下的脑磁共振影像改变，旨在为进一步探索双相障碍自杀的病理生理机制提供参考。

关键词: 双相障碍, 自杀意念, 自杀未遂, 磁共振影像, 脑

Abstract:

Bipolar disorder, as a major mental illness, has a high lifetime suicide attempt rate in patients, and suicidal behavior is most likely to occur during depressive episodes. Therefore, in-depth study of its mechanism is essential for prevention, early detection and intervention of suicide. With the development of magnetic resonance imaging (MRI) technology, it has been found that there are abnormalities in the brain structure and function in suicidal patients with bipolar disorder. This article reviews the studies on suicide in bipolar disorder patients by MRI from four aspects: structure, function, structure-function, and central metabolism and cerebral blood flow perfusion, and summarizes the suicide-related changes. This review focuses on distinguishing the brain MRI changes under different mood states and diverse definitions of suicide, aiming to provide reference for further exploration of the pathophysiological mechanism of suicide in bipolar disorder.

Key words: bipolar disorder, suicidal ideation, suicidal attempt, magnetic resonance imaging (MRI), brain

中图分类号:

R749.4

陈嘉烨, 张慧凤, 卢文仙, 彭代辉. 双相障碍患者自杀相关脑磁共振影像研究进展[J]. 上海交通大学学报（医学版）, 2023, 43(7): 939-944.

CHEN Jiaye, ZHANG Huifeng, LU Wenxian, PENG Daihui. Research progress of brain magnetic resonance imaging related to suicide in bipolar disorder patients[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(7): 939-944.

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双相障碍患者自杀相关脑磁共振影像研究进展

Research progress of brain magnetic resonance imaging related to suicide in bipolar disorder patients

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