上海交通大学学报(医学版) ›› 2021, Vol. 41 ›› Issue (2): 241-245.doi: 10.3969/j.issn.1674-8115.2021.02.018

• 综述 • 上一篇    

快感缺失的炎症机制研究进展

吴则南(), 张晨()   

  1. 上海交通大学医学院附属精神卫生中心生化药理研究室,上海 200030
  • 收稿日期:2020-02-14 出版日期:2021-02-28 发布日期:2021-03-11
  • 通讯作者: 张晨 E-mail:zenan_wu@163.com;zhangchen645@gmail.com
  • 作者简介:吴则南(1996—),男,硕士生;电子信箱:zenan_wu@163.com
  • 基金资助:
    国家重点研发计划(2018YFC1314302);国家自然科学基金(81471358);上海市科学技术委员会西医引导类项目(19411969300);上海市教育委员会高峰高原学科建设计划(20152530)

Research advances in inflammatory mechanism of anhedonia

Ze-nan WU(), Chen ZHANG()   

  1. Biochemical Pharmacology Laboratory, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Received:2020-02-14 Online:2021-02-28 Published:2021-03-11
  • Contact: Chen ZHANG E-mail:zenan_wu@163.com;zhangchen645@gmail.com
  • Supported by:
    National Key Research and Development Program of China(2018YFC1314302);National Natural Science Foundation of China(81471358);Western Medicine Guide Project of Science and Technology Commission of Shanghai Municipality(19411969300);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20152530)

摘要:

快感缺失存在于多种精神疾病,是预测患者转归的重要指标。完善快感缺失的概念,深入探究其机制,从而进一步明确其病理生理学基础,有利于相关疾病的诊断和治疗。近年来,大量研究表明机体炎症状态下犬尿氨酸途径与四氢生物蝶呤代谢的异常会导致奖赏环路神经损伤和递质紊乱,与快感缺失的发生和发展密切相关。该文以此为重点,对快感缺失炎症机制的研究进展进行综述。

关键词: 快感缺失, 奖赏回路, 炎症, 犬尿氨酸途径, 四氢生物蝶呤

Abstract:

Anhedonia, a typical symptom of many mental diseases, is also an important indicator for treatment outcome. Further exploration of the mechanism of anhedonia and clear definition and illustration of its pathophysiological basis are helpful to the diagnosis and treatment of related diseases. In recent years, converging evidence has implicated that inflammation-driven alterations in kynurenine pathway (KP) and tetrahydrobiopterin (BH4) metabolism lead to nerve injury and disturbance of neurotransmitter in reward circuit, which is closely related to the emergence and development of anhedonia. Therefore, this review aims to summarize the research advances in the inflammatory mechanism of anhedonia, with the emphasis on both KP and BH4 metabolism.

Key words: anhedonia, reward circuit, inflammation, kynurenine pathway, tetrahydrobiopterin

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