上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (8): 1068-.doi: 10.3969/j.issn.1674-8115.2012.08.022

• 论著（临床研究） • 上一篇    下一篇

18F-FDG PET/CT显像在131I全身扫描及血清Tg均阴性的已清除残留甲状腺组织的分化型甲状腺癌患者中的应用价值

程维维, 王 辉, 冯 方, 傅宏亮, 李佳宁   

  1. 上海交通大学 医学院附属新华医院核医学科, 上海 200092
  • 出版日期:2012-08-28 发布日期:2012-08-29
  • 通讯作者: 王 辉, 电子信箱: wanghuishanghai@hotmail.com。
  • 作者简介:程维维（1988—）, 女, 硕士生；电子信箱: chengweiwei37@126.com。
  • 基金资助:

    上海市重点学科建设项目（S30203）

Application of 18F-FDG PET/CT in patients with negative findings in serum Tg measurement and 131I-whole body scan after ablation of remaining thyroid tissues for differentiated thyroid carcinoma

CHENG Wei-wei, WANG Hui, FENG Fang, FU Hong-liang, LI Jia-ning   

  1. Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2012-08-28 Published:2012-08-29
  • Supported by:

    Shanghai Leading Academic Discipline Project, S30203

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摘要：

目的 探讨18F-FDG PET/CT显像在血清Tg和131I全身扫描均为阴性的行甲状腺癌切除和清除残留甲状腺组织治疗后的患者中检测肿瘤复发和转移的应用价值。方法 41例接受了甲状腺全切和大剂量131I清除残留甲状腺组织治疗的DTC患者，在随访中进行了血清Tg测定、131I-WBS、颈部B超、胸部CT及18F-FDG PET/CT全身显像。结果 41例患者血清Tg和131I-WBS均为阴性，颈部B超或胸部CT均显示存在异常病灶；其中23例患者18F-FDG PET/CT显像阳性，18例患者18F-FDG PET/CT显像阴性。18F-FDG PET/CT显像阳性患者中，有3例经病理检查证实为甲状腺癌转移；18F-FDG PET/CT显像阳性病灶与阴性病灶的长短径差异无统计学意义。结论 接受甲状腺全切和大剂量131I清除残留甲状腺组织治疗后的DTC患者术后随访血清Tg及131I-WBS均为阴性时，18F-FDG PET/CT显像可显示可疑的阳性病灶，有助于发现复发和转移病灶。

关键词: 分化型甲状腺癌, 131I全身扫描, 血清甲状腺球蛋白, 18F-FDG

Abstract:

Objective To investigate the application of 18F-FDG PET/CT in detection of tumor  recurrence and metastasis among patients with negative findings in serum thyroglobulin (Tg) measurement and 131I-whole body scan (131I-WBS) after total thyroidectomy and 131I ablation of the remaining thyroid tissues for differentiated thyroid carcinoma (DTC). Methods Forty-one patients with DTC underwent total thyroidectomy and 131I ablation of the remaining thyroid tissues, and were followed up with serum Tg measurement, 131I-WBS, neck ultrasound, chest CT and whole body 18F-FDG PET/CT. Results All these 41 patients had negative findings in serum Tg measurement and 131I-WBS, while abnormal lesions were detected by neck ultrasound or chest CT. Twenty-three patients had positive findings in 18F-FDG PET/CT, 3 of whom were confirmed as thyroid carcinoma metastases by pathological examinations. There was no significant difference between the size of 18F-FDG PET/CT positive lesions and that of 18F-FDG PET/CT negative lesions. Conclusion 18F-FDG PET/CT may demonstrate suspicious positive lesions in patients with negative findings in serum Tg measurement and 131I-WBS after total thyroidectomy and 131I ablation of the remaining thyroid tissues for DTC, which may help in the detection of tumor recurrence and metastasis.

Key words: differentiated thyroid carcinoma, 131I whole body scan, serum thyroglobulin, 18F-FDG